Sildenafil spray approved for erectile dysfunction in Germany, Ireland, and the Netherlands

Sildenafil has shown some potential for improving exercise performance at high altitudes.

Society and culture

Hezkue 12.5mg per actuation, oral suspension was developed by the specialty pharmaceutical group Aspargo Laboratories Inc. in partnership with their commercialization consultant, Syneos Health. The 2 groups held focus groups and conducted surveys with physicians, pharmacists, and patients throughout the development process. Aspargo uses a metered-dose pump so that it can deliver the precise, customized dose per push based on the needs of the patient. According to Aspargo, Sildenafil spray is also discreet, easy to carry, and allows patients to avoid crushing or splitting pills with the traditional tablet medications currently available for ED.

Raynaud's phenomenon

Aspargo Laboratories is currently seeking FDA approval to market Sildenafil spray in the United States. Aspargo receives regulatory approval to market sildenafil spray in Germany, Ireland, and the Netherlands. When you get aroused, your body produces a molecule called cGMP which helps to stimulate an erection by increasing blood flow to the penis.1 All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Viagra Connect was the first erectile dysfunction (ED) treatment available in the UK without a prescription. It contains sildenafil, the same active ingredient found in prescription Viagra, which is a medicine that’s been trusted by millions of men worldwide since it first came to market in the late 1990s. However, its overall efficacy is not clear.

Sildenafil has been studied for high-altitude pulmonary edema (HAPE), but its use is currently not recommended for that indication.

The Distinction Between Brands and Generics

[11] It was approved for medical use in the United States and in the European Union in 1998. [5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse). In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision.

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[8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). [8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. [8] Caution is advised in those with cardiovascular disease. [8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis.

Data collection

[8] Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [4] Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).

Navigating Risks and Contraindications

Its use is now one of the standard treatments for erectile dysfunction, including for males with diabetes mellitus. Tentative evidence suggests that sildenafil may help males who experience antidepressant-induced erectile dysfunction. While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon;[9][21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9] As of 2016,[update] their role more generally in Raynaud's was not clear. [24] This cyanopsia can be explained because sildenafil, while selective for PDE5, does have some affinity for PDE6, which is the phosphodiesterase found in the retina.

UK DOCTORS AND CLINICIANS

And if plans change, so can your delivery, all online. With thousands of successful patients behind us, our approach is tried, tested, and trusted. Viagra Connect has the same side effect profile as both Viagra and generic sildenafil. Some of these side effects can be found in the table below, and for a full list of side effects, please read the Patient Information Leaflet found in each box.2 Find the clinically proven ED treatment that suits you best. Specialists in medicine, nutrition, performance, and diagnostics.

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BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Viagra Connect 50 mg film-coated tablets. Viagra Connect 50 mg film-coated tablets. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if oral sildenafil it is effective for treating sexual dysfunction in females. Patients thus taking the drug may experience colorvision abnormalities.

Some complained of blurriness and loss of peripheral vision.

In July 2005, the US Food and Drug Administration (FDA) updated labeling for tadalafil (Cialis), vardenafil (Levitra), and sildenafil

• Sildenafil prices in Ireland can differ based on the seller’s markup.
• Certified online pharmacies tend to provide competitive sildenafil prices.
• In Ireland, sildenafil is available only with a prescription, influencing prices.
• Special discounts or promotions may reduce sildenafil costs temporarily.
• Importing sildenafil independently carries risks and may be illegal.

(Viagra) to reflect a small number of post-marketing reports of sudden vision loss, while acknowledging that "...it is not possible

• Online pharmacies in Ireland often offer discounts on sildenafil bulk packs.
• Prices can be influenced by dosage strength and brand reputation.
• Local Irish pharmacies may charge higher prices compared to online options.
• Some Irish clinics prescribe sildenafil, including consultation fees.
• Over-the-counter availability of sildenafil is limited in Ireland.

to determine whether these oral medicines for erectile dysfunction were the cause of the loss of eyesight or whether the problem is related to other factors such as high blood pressure or diabetes, or to a combination of these problems.

Can You Buy Viagra Online Legally in Europe?

It's a common condition that can affect men of all ages. Our ED category offers a variety of treatment options. We stock Sildenafil, the generic equivalent to Viagra, for purchase after a consultation with our pharmacy team. Viagra Connect is also available, a pharmacy-only medication containing Sildenafil for suitable patients. The spray is a liquid suspension of sildenafil citrate administered orally via a spray pump.

What Is Generic Sildenafil?

The German Federal Institute for Drugs and Medical Devices has granted regulatory approval to market Sildenafil oral spray (trade name, Hezkue) for erectile dysfunction (ED) in Germany. The spray was also recently approved for marketability in Ireland and the Netherlands, according to a news release from Aspargo Laboratories, the developer of the treatment.1 The German market is the largest in the EU, and the aggregate erectile dysfunction market for Germany, Ireland, and the Netherlands exceeds $175 million. “These product approvals reflect Aspargo’s commitment to quickly expand its global platform to the EU during 2023. The Marketing Authorizations are an important achievement. They validate Aspargo’s international regulatory strategy and confirm that Aspargo meets the highest standards required to ensure the safe distribution of sildenafil spray,” said Michael Demurjian, Chairman and Chief Executive Officer of Aspargo. "[25] A careful review of pooled data from clinical trials containing well documented information about the dose and duration of exposure to the drug for a large number of patients, yields no evidence for an increased risk of non-arteritic anterior ischemic optic neuropathy or other adverse ocular events associated with PDE5 inhibitor use.

• The price of sildenafil in Ireland may increase with newer, branded products.
• Irish law requires a prescription, ensuring safer sildenafil purchase options.
• Discounts are sometimes available during Irish health awareness events.
• Consult a doctor to discuss affordable and safe sildenafil options.
• Comparing prices on Irish pharmacy websites helps find the best deal.

Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss.

Comparable Medicines and Preferences

Launched as an over-the-counter option in 2018, Viagra Connect was developed to make ED treatment more accessible and discreet. Instead of needing a GP appointment, it can now be purchased directly following a short consultation or assessment with a pharmacist. Viagra Connect, which contains sildenafil, typically takes around 30-60 minutes to start working and lasts for up to 4 hours.1 When you get aroused, your body produces a molecule called cGMP which helps to stimulate an erection by increasing blood flow to the penis.1 However, for people experiencing erectile difficulties, an enzyme known as PDE5 normally breaks cGMP down, restricting blood flow and causing the erection to subside.1 Viagra Connect blocks the action of PDE5, allowing more blood to flow to the penis. The resulting erection is firmer and usually lasts long enough to allow for satisfying sex.1 The difference between Viagra and Viagra Connect is that Viagra is only available via a prescription, whereas Viagra Connect can be bought over the counter without a prescription. We’re a holistic health platform built to help you take control, with treatment, guidance, and ongoing support that actually works.

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When you choose Viagra Connect with Numan, you’re not just getting medication, but complete care designed to help you perform your best. Complete a Numan Erectile Dysfunction Blood Test to uncover underlying causes such as low testosterone or cardiovascular risk factors, so you can get more effective treatment. Get access to our doctors and clinicians should you require any medical help with your treatment. If hormone issues related to erectile dysfunction are suspected, Numan offers access to a dedicated team who provide personalised treatment, monitoring, and support. All treatments are shipped quickly for free, in discreet packaging directly to your desired address. [4] In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss.